Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30034914 | 0.85 | ALDH1A1 (0.67) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL11476904 | 0.85 | RAB9A (0.63) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL2077026 | 0.85 | ALDH1A1 (0.67) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6071536 | 0.83 | GSK3B (0.54) | GSK3BKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL1243431 | 0.83 | RAB9A (0.50) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL13387475 | 0.83 | TP53 (0.59) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6269930 | 0.83 | XDH (0.68) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL3871613 | 0.81 | KDM4E (0.74) | GSK3BKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL2499455 | 0.79 | XDH (0.71) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL838694 | 0.78 | CYP17A1 (0.46) | GSK3BCYP1A2RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060167020-A1 | Pyrazolopyrimidines as kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2006-07-27 | — | — | US | disclosed |
| EP-1523314-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004009597-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009597-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167020-A1 | Pyrazolopyrimidines as kinase inhibitors | MAP3K12, MAP3K5, MAP3K2 | GSK3B 591/4885KDM4E 1432/4885ALDH1A1 2729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.