Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071424 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6071875 | 0.80 | KDM4E (0.42) | ALDH1A1KDM4EKMT2AHTTADORA2A | |
| SCHEMBL6071641 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6072069 | 0.80 | KDM4E (0.50) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6071687 | 0.77 | KDM4E (0.41) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6072091 | 0.74 | ADRA2A (0.45) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6071945 | 0.73 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6071926 | 0.71 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL6265005 | 0.70 | TLR8 (0.64) | ALDH1A1KDM4ENPSR1HSD17B10GAA | |
| SCHEMBL6252164 | 0.70 | KDM4E (0.60) | ALDH1A1KDM4EKMT2AHTTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ALDH1A1 3975/4885KDM4E 1032/4885KMT2A 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.