Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139697 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL6072069 | 0.87 | KDM4E (0.50) | ALDH1A1KDM4EAPPMEN1KMT2A | |
| SCHEMBL6071926 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL6265005 | 0.82 | TLR8 (0.64) | ALDH1A1KDM4ENPSR1TLR8GAA | |
| SCHEMBL7999933 | 0.78 | MEN1 (0.51) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL6252164 | 0.76 | KDM4E (0.60) | ALDH1A1KDM4EKMT2AHTTADORA2A | |
| SCHEMBL6071664 | 0.76 | NCF1 (0.41) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL6071998 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL6071923 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL27975057 | 0.74 | MEN1 (0.49) | ALDH1A1KDM4EMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ALDH1A1 3975/4885KDM4E 1032/4885ABCB1 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.