Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139696 | 0.87 | RXFP1 (0.41) | KDM4EALDH1A1ADORA2AHSD17B10HPGD | |
| SCHEMBL7999931 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1ADORA2AHSD17B10ADORA1 | |
| SCHEMBL6071934 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1TLR7TLR8ADORA2A | |
| SCHEMBL6253855 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1TLR7TLR8ADORA2A | |
| SCHEMBL30315435 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1TLR7TLR8ADORA2A | |
| SCHEMBL6252164 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1ADORA2AHSD17B10HPGD | |
| SCHEMBL6071662 | 0.75 | CACNA2D1 (0.43) | KDM4EALDH1A1LMNATP53MAPT | |
| SCHEMBL6071996 | 0.75 | ADORA2A (0.46) | KDM4EALDH1A1ADORA2AHSD17B10HPGD | |
| SCHEMBL6072133 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1ADORA2AHSD17B10HTT | |
| SCHEMBL3521028 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | KDM4E 1032/4885ALDH1A1 3975/4885TLR7 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.