Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 11/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636725 | 0.74 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL3518114 | 0.74 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6071941 | 0.73 | KDM4E (0.47) | KDM4EALDH1A1IKBKBADORA2AHSD17B10 | |
| SCHEMBL6779214 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6252164 | 0.71 | KDM4E (0.60) | KDM4EALDH1A1CYP1A2ADORA2AHSD17B10 | |
| SCHEMBL6071926 | 0.69 | ALDH1A1 (0.46) | KDM4EALDH1A1IKBKBADORA2AHSD17B10 | |
| SCHEMBL3521028 | 0.68 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6253855 | 0.68 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2ADORA2AHSD17B10 | |
| SCHEMBL31636611 | 0.68 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL30315435 | 0.68 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2ADORA2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | KDM4E 1032/4885ALDH1A1 3975/4885IKBKB 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.