Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Farnesol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | ICMT | O60725 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Geraniol SCHEMBL28550399 | 0.99 | CYP3A4 (0.57) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| Farnesol SCHEMBL3040180 | 0.83 | MAPT (0.61) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| Geraniol SCHEMBL28645505 | 0.81 | CYP3A4 (0.59) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| Farnesol SCHEMBL28074103 | 0.80 | MAPT (0.65) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| SCHEMBL15345638 | 0.78 | MAPT (0.62) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| SCHEMBL13356402 | 0.78 | ICMT (0.62) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| SCHEMBL147321 | 0.77 | ICMT (0.58) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| SCHEMBL6072531 | 0.77 | TRPV1 (0.59) | ALOX15ALDH1A1 | |
| Farnesol SCHEMBL19555654 | 0.77 | MAPT (0.61) | MAPTCYP3A4ICMTGMNNTRPA1 | |
| Farnesol SCHEMBL29087994 | 0.77 | KMT2A (0.83) | MAPTCYP3A4TRPA1MEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083666-A1 | ANTI-INFLAMMATORY SUPPLEMENT COMPOSITIONS AND REGIMENS TO REDUCE CARDIOVASCULAR DISEASE RISKS | A.M. TODD COMPANY (US) | 2006-08-10 | — | — | WO | disclosed |