Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 5/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071927 | 0.83 | KDR (0.52) | RAF1BRAFKDRNFKB1NR2C2 | |
| SCHEMBL6072111 | 0.83 | KDR (0.53) | RAF1BRAFKDRNFKB1NR2C2 | |
| SCHEMBL6072414 | 0.83 | KDR (0.52) | RAF1BRAFKDRNFKB1NR2C2 | |
| SCHEMBL6071883 | 0.82 | KDR (0.51) | RAF1BRAFKDRNFKB1NR2C2 | |
| SCHEMBL6072418 | 0.80 | KDR (0.47) | RAF1BRAFKDRMAPK14 | |
| SCHEMBL6072374 | 0.79 | KDR (0.58) | RAF1BRAFKDRNPC1RAB9A | |
| SCHEMBL14793110 | 0.79 | KDR (0.69) | RAF1BRAFMEN1KMT2AKDR | |
| SCHEMBL6072949 | 0.79 | KDR (0.51) | RAF1BRAFKDRNFKB1NR2C2 | |
| SCHEMBL6072483 | 0.79 | KDR (0.61) | RAF1BRAFMEN1KMT2AKDR | |
| SCHEMBL14793075 | 0.78 | KDR (0.70) | RAF1BRAFMEN1KMT2AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | ADAMS JERRY L | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | CHKB, MAP3K20, MAP3K6 | RAF1 205/4885BRAF 191/4885MEN1 3087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.