Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073629 | 0.90 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL20266375 | 0.84 | HPGD (0.48) | ALDH1A1HPGDKMT2ALMNACYP2C19 | |
| SCHEMBL30676150 | 0.84 | HPGD (0.48) | ALDH1A1HPGDKMT2ALMNACYP2C19 | |
| SCHEMBL20703988 | 0.82 | RAB9A (0.46) | ALDH1A1HPGDKMT2ARAB9ALMNA | |
| SCHEMBL6073244 | 0.81 | NPSR1 (0.37) | KMT2ALMNAMEN1MAPTCYP1A2 | |
| SCHEMBL2756208 | 0.80 | CNR2 (0.43) | ALDH1A1HPGDKDM4EKMT2ARAB9A | |
| SCHEMBL15713808 | 0.78 | CNR2 (0.42) | ALDH1A1HPGDKDM4EKMT2ARAB9A | |
| SCHEMBL1585857 | 0.76 | CYP1A2 (0.48) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL8253940 | 0.76 | KMT2A (0.39) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL25299222 | 0.76 | KMT2A (0.47) | ALDH1A1KDM4EHSD17B10KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |