Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073329 | 0.90 | ALDH1A1 (0.39) | ALDH1A1HPGDKMT2ARAB9AKDM4E | |
| SCHEMBL30676150 | 0.86 | HPGD (0.48) | ALDH1A1HPGDKMT2ACYP2C19NPSR1 | |
| SCHEMBL20266375 | 0.86 | HPGD (0.48) | ALDH1A1HPGDKMT2ACYP2C19NPSR1 | |
| SCHEMBL6073244 | 0.83 | NPSR1 (0.37) | KMT2AMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20703988 | 0.82 | RAB9A (0.46) | ALDH1A1HPGDKMT2ARAB9APOLB | |
| SCHEMBL1585857 | 0.81 | CYP1A2 (0.48) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL25299222 | 0.78 | KMT2A (0.47) | ALDH1A1KMT2ARAB9AKDM4EPOLB | |
| SCHEMBL16913890 | 0.75 | HDAC4 (0.48) | KMT2ARAB9AKDM4EMAPTMEN1 | |
| SCHEMBL3715020 | 0.75 | CA1 (0.39) | KMT2ARAB9AMAPTMEN1 | |
| SCHEMBL2756208 | 0.74 | CNR2 (0.43) | ALDH1A1HPGDKMT2ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |