Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.51 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663947 | 0.81 | RIPK1 (0.46) | RIPK1BRD4TSHRKMT2AALDH1A1 | |
| SCHEMBL9815162 | 0.75 | KMT2A (0.35) | RIPK1BRD4TSHRKMT2AALDH1A1 | |
| SCHEMBL30259456 | 0.74 | TSHR (0.39) | RIPK1TSHRKMT2AALDH1A1 | |
| SCHEMBL7387880 | 0.74 | TSHR (0.39) | RIPK1TSHRKMT2AALDH1A1 | |
| SCHEMBL9386008 | 0.73 | RIPK1 (0.33) | RIPK1 | |
| SCHEMBL9079730 | 0.73 | RIPK1 (0.44) | RIPK1BRD4TSHRKMT2AALDH1A1 | |
| SCHEMBL24775446 | 0.73 | RIPK1 (0.55) | RIPK1BRD4TSHRKMT2AALDH1A1 | |
| SCHEMBL10540453 | 0.72 | — | — | |
| SCHEMBL7434830 | 0.70 | — | — | |
| SCHEMBL7434835 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119207-B2 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC (US) | 2006-10-10 | — | — | US | disclosed |
| EP-0719253-B1 | 3-AMINO-5-CARBOXY-SUBSTITUTED PIPERIDINES AND 3-AMINO-4-CARBOXY-SUBSTITUTED PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER (US) | 2004-04-28 | — | — | EP | disclosed |
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| EP-1272484-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001077100-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2001-10-18 | — | — | WO | disclosed |
| US-6083943-A | FOR TREATMENT OF GASTROINTESTINAL DISORDERS, CENTRAL NERVOUS SYSTEM DISORDERS, ALLERGY, INFLAMMATORY DISEASES, ASTHMA, PAIN, EMESIS OR MIGRAINE IN MAMMALS, ESPECIALLY HUMANS | PFIZER INC (US) | 2000-07-04 | — | — | US | disclosed |
| WO-1995007886-A1 | 3-AMINO-5-CARBOXY-SUBSTITUTED PIPERIDINES AND 3-AMINO-4-CARBOXY-SUBSTITUTED PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER INC. (US) | 1995-03-23 | — | — | WO | disclosed |
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1991009844-A1 | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | TACR1, VIPR1, VIPR2 | RIPK1 3759/4885BRD4 828/4885TSHR 2536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.