Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073850 | 0.73 | RIPK1 (0.51) | RIPK1KMT2AALDH1A1BRD4TSHR | |
| SCHEMBL4698531 | 0.72 | ACE (0.33) | KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL9197329 | 0.71 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL28497094 | 0.71 | RIPK1 (0.49) | RIPK1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL9194062 | 0.69 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL30054156 | 0.68 | RIPK1 (0.53) | RIPK1KMT2AALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL17870940 | 0.68 | RIPK1 (0.53) | RIPK1KMT2AALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL17870941 | 0.68 | RIPK1 (0.53) | RIPK1KMT2AALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL10663947 | 0.68 | RIPK1 (0.46) | RIPK1KMT2AALDH1A1BRD4TSHR | |
| SCHEMBL17870936 | 0.65 | RIPK1 (0.49) | RIPK1KMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719253-A1 | 3-AMINO-5-CARBOXY-SUBSTITUTED PIPERIDINES AND 3-AMINO-4-CARBOXY-SUBSTITUTED PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-07-03 | — | — | EP | disclosed |