Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.56 |
| ▸ | IKBKB | O14920 | 11/20 | 0.52 |
| ▸ | CHUK | O15111 | 10/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20884066 | 0.81 | IKBKB (0.56) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL10851167 | 0.78 | ADRB1 (0.60) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL29898213 | 0.73 | IKBKB (0.62) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL10855572 | 0.73 | ADRB1 (1.00) | ADRB1IKBKBCHUKKDM4ELMNA | |
| SCHEMBL552112 | 0.72 | IKBKB (0.60) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL28335692 | 0.72 | IKBKB (0.60) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL7130762 | 0.72 | ADRB3 (0.57) | ADRB1IKBKBCHUKADRB2ADRA2C | |
| SCHEMBL20884986 | 0.70 | IKBKB (0.57) | ADRB1IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL6075622 | 0.69 | ADRB2 (0.62) | ADRB1BLMKDM4ERECQLMAPT | |
| SCHEMBL9135589 | 0.69 | ADRB2 (0.62) | ADRB1BLMKDM4ERECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521606-A | 5-Indolyl substituted aminoethanols | AMERICAN HOME PRODUCTS CORP. (US) | 1985-06-04 | — | — | US | claimed |
| US-7022716-B2 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| CN-1455771-A | Cyclic amine phenyl Beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | disclosed |
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2003-07-31 | — | — | US | disclosed |
| US-6525202-B2 | E.g., substituted (4-amino-5-hydroxyphenyl)-oxy-)piperidinyl thiazolidin-2,4-dione; antidiabetic agents; atherosclerosis, gastrointestinal, metabolic disorders, glaucoma, neurogenetic inflammation, ocular hypertension and frequent urination | WYETH | 2003-02-25 | — | — | US | disclosed |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2002-03-07 | — | — | US | disclosed |
| US-4622399-A | Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| US-4562200-A | 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| US-4521606-A | 5-Indolyl substituted aminoethanols | AMERICAN HOME PRODUCTS CORP. (US) | 1985-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | ADRB1 1/4885IKBKB 1472/4885CHUK 497/4885 |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | ADRB1 1/4885IKBKB 1472/4885CHUK 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.