Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490761 | 0.90 | OPRL1 (0.43) | KMT2AMEN1OPRL1KCNH2KEAP1 | |
| SCHEMBL6080094 | 0.86 | BACE1 (0.41) | KMT2AMEN1OPRL1KCNH2KEAP1 | |
| SCHEMBL6076026 | 0.86 | ALDH1A1 (0.40) | KMT2AMEN1OPRL1KCNH2KEAP1 | |
| SCHEMBL6501862 | 0.85 | BACE1 (0.42) | KMT2AMEN1KCNH2TSHRNPSR1 | |
| SCHEMBL6081664 | 0.84 | RBP4 (0.44) | OPRL1 | |
| SCHEMBL6075129 | 0.84 | RBP4 (0.50) | — | |
| SCHEMBL6075935 | 0.84 | KMT2A (0.40) | KMT2AMEN1OPRL1TSHRNPSR1 | |
| SCHEMBL6264475 | 0.83 | RORC (0.38) | KMT2AMEN1OPRL1KCNH2KEAP1 | |
| SCHEMBL6076082 | 0.83 | OPRL1 (0.38) | KMT2AMEN1OPRL1KCNH2TSHR | |
| SCHEMBL6079726 | 0.83 | KMT2A (0.40) | KMT2AMEN1OPRL1KCNH2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115633-B2 | Central nervous system disorders; Alzheimer's diseases; eating disorders | GLAXOSMITHKLINE S.P.A. (IT) | 2006-10-03 | — | — | US | disclosed |
| EP-1278729-B1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GLAXOSMITHKLINE SPA (IT) | 2005-11-09 | — | — | EP | disclosed |
| EP-1278729-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GlaxoSmithKline S.p.A. (IT) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083454-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GLAXOSMITHKLINE S.P.A. (IT) | 2001-11-08 | — | — | WO | disclosed |