Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B17 | O75795 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 9/20 | 0.36 |
| ▸ | NPC1 | O15118 | 8/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618385 | 0.80 | SLC18A3 (0.39) | SRCSLC18A3RAB9AGAACYP1A2 | |
| SCHEMBL6075092 | 0.65 | ACHE (0.35) | SLC18A3RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31146782 | 0.65 | HRH2 (0.35) | UGT2B17SRCSLC18A3RAB9ANPC1 | |
| SCHEMBL6100514 | 0.65 | ACHE (0.44) | HPGDALDH1A1MAPTMAPK1 | |
| SCHEMBL1655387 | 0.65 | — | — | |
| SCHEMBL11864089 | 0.65 | UGT2B17 (0.37) | UGT2B17RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL5752195 | 0.64 | UGT2B17 (0.51) | UGT2B17 | |
| SCHEMBL728734 | 0.64 | NISCH (0.35) | SLC18A3POLBALDH1A1 | |
| SCHEMBL10703006 | 0.63 | HPGD (0.46) | HPGDSMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL8130405 | 0.63 | HRH2 (0.44) | SLC18A3RAB9ANPC1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | disclosed |