Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609097 | 1.00 | NPC1 (0.44) | NPC1CA1CA2CA12CA9 | |
| SCHEMBL271893 | 1.00 | — | — | |
| SCHEMBL193484 | 0.97 | — | — | |
| SCHEMBL128439 | 0.91 | — | — | |
| SCHEMBL4362759 | 0.88 | NPC1 (0.38) | NPC1CA1CA2EPHX1 | |
| SCHEMBL10694762 | 0.84 | — | — | |
| SCHEMBL130689 | 0.84 | — | — | |
| SCHEMBL4356308 | 0.81 | NPC1 (0.32) | NPC1 | |
| SCHEMBL6532830 | 0.79 | NPC1 (0.30) | NPC1 | |
| SCHEMBL6379649 | 0.78 | NPC1 (0.52) | NPC1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347597-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUND FOR THE TREATMENT OF DERMAL DISORDERS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2024-04-10 | — | — | EP | disclosed |
| WO-2024064178-A1 | HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2024-03-28 | — | — | WO | disclosed |
| CN-117377674-A | Pyrazolo [1,5-a ] pyrimidine compounds for the treatment of dermatological disorders | 大塚制药株式会社 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023233895-A1 | POLYIMIDE RESIN PRECURSOR | 東京応化工業株式会社 | 2023-12-07 | — | — | WO | disclosed |
| WO-2023233896-A1 | PHOTOSENSITIVE RESIN COMPOSITION | 東京応化工業株式会社 | 2023-12-07 | — | — | WO | disclosed |
| WO-2023176172-A1 | POLYIMIDE RESIN PRECURSOR | 東京応化工業株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022255408-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUND FOR THE TREATMENT OF DERMAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2022-12-08 | — | — | WO | disclosed |
| EP-3590940-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2021-06-09 | — | — | EP | disclosed |
| US-10913745-B2 | Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2021-01-21 | — | — | US | disclosed |
| EP-0880531-A1 | SUBSTITUTED 2-PHENYLPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-02 | — | — | EP | disclosed |
| EP-0879239-A1 | SUBSTITUTED AROMATIC PHOSPHONIC ACID DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-25 | — | — | EP | disclosed |
| WO-1998038169-A1 | SUBSTITUTED 3-PHENYL PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-03 | — | — | WO | disclosed |
| WO-1998027090-A2 | SUBSTITUTED PYRAZOLE-3-YL BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| US-5770346-A | BRIDGED CYCLIC HYDROCARBON GROUP-CONTAINING ACRYLATE POLYMER | NEC CORPORATION (JP) | 1998-06-23 | — | — | US | disclosed |
| WO-1998007720-A1 | SUBSTITUTED 2-ARYLPYRIDINE AS HERBICIDE | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-26 | — | — | WO | disclosed |
| WO-1998005649-A1 | SUBSTITUTED 3-PHENYL PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-12 | — | — | WO | disclosed |
| WO-1997030059-A1 | SUBSTITUTED 2-PHENYLPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 1997-08-21 | — | — | WO | disclosed |
| WO-1997030060-A1 | SUBSTITUTED AROMATIC PHOSPHONIC ACID DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1997-08-21 | — | — | WO | disclosed |
| US-4198429-A | BRONCHOSPASMOLYTIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913745-B2 | Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors | ENPP2, TPX2, PRAP1 | NPC1 3948/4885CA1 2173/4885CA2 2616/4885 |
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | NPC1 1467/4885CA1 2697/4885CA2 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.