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SCHEMBL6077582

SCHEMBL6077582

COC(=O)c1cc(S(=O)(=O)Nc2ccc3ccc(/N=C(/Nc4ccc5ccc(NS(=O)(=O)c6ccc(Cl)c(C(=O)OC)c6)cc5c4)N(C)C)cc3c2)ccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.52
▸ LMNA P02545 1/20 0.52
▸ GAA P10253 1/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ MAPT P10636 2/20 0.43
▸ TSHR P16473 1/20 0.42
▸ PLAU P00749 3/20 0.42
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6079241 0.91 KMT2A (0.49) ALDH1A1LMNAGAAMEN1KMT2A
SCHEMBL6078213 0.85 ALDH1A1 (0.59) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078839 0.84 LMNA (0.55) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078668 0.84 LMNA (0.55) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6079065 0.82 ALDH1A1 (0.59) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078277 0.81 LMNA (0.67) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6079143 0.80 ALDH1A1 (0.64) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078676 0.80 LMNA (0.64) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078043 0.79 ALDH1A1 (0.59) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL6078993 0.79 ALDH1A1 (0.55) ALDH1A1LMNAGAAL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed