Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077812 | 0.90 | MAP2K1 (0.47) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL6078482 | 0.90 | MAPT (0.52) | KDM4EMAPTALDH1A1LMNARAB9A | |
| SCHEMBL6076379 | 0.85 | MAP2K1 (0.53) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6078018 | 0.84 | ALDH1A1 (0.62) | KDM4EMAPTALDH1A1LMNAMEN1 | |
| SCHEMBL6077798 | 0.81 | RAB9A (0.53) | KDM4EMAPTALDH1A1LMNARAB9A | |
| SCHEMBL6079512 | 0.79 | ALDH1A1 (0.53) | KDM4EMAPTALDH1A1LMNARAB9A | |
| SCHEMBL6077742 | 0.78 | MAP2K1 (0.53) | KDM4EMAPTALDH1A1MAOAMAOB | |
| SCHEMBL6078589 | 0.78 | MAP2K1 (0.53) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6077069 | 0.77 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1LMNAMAOA | |
| SCHEMBL6076930 | 0.77 | MAP2K1 (0.52) | KDM4EMAPTRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | claimed |
| EP-1603882-A2 | UREA AND THIOUREA DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004072044-A2 | UREA AND THIOUREA DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-26 | — | — | WO | claimed |
| US-7074933-B2 | Urea and thiourea derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1603882-A2 | UREA AND THIOUREA DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040266820-A1 | Urea and thiourea derivatives | DU DANIEL Y (US) | 2004-12-30 | — | — | US | disclosed |
| WO-2004072044-A2 | UREA AND THIOUREA DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266820-A1 | Urea and thiourea derivatives | SHBG, ZP1, ZYX | KDM4E 153/4885MAPT 878/4885ALDH1A1 4212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.