Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.48 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520951 | 0.96 | TCF4 (0.53) | TCF4CTNNB1PRMT1IDH1NPC1 | |
| SCHEMBL6428056 | 0.90 | PRMT1 (0.58) | PRMT1IDH1SIRT1PLAU | |
| SCHEMBL6078536 | 0.89 | PRMT1 (0.60) | PRMT1MAPTSIRT1MEN1KMT2A | |
| SCHEMBL6078502 | 0.88 | PRMT1 (0.58) | PRMT1SIRT1MEN1KMT2APOLB | |
| SCHEMBL28327806 | 0.87 | TCF4 (0.61) | TCF4CTNNB1RAB9APOLBPLAU | |
| SCHEMBL6078100 | 0.85 | TCF4 (0.68) | TCF4CTNNB1IDH1NPC1MAPT | |
| SCHEMBL6078550 | 0.85 | PRMT1 (0.68) | PRMT1MAPTSIRT1MEN1KMT2A | |
| SCHEMBL6427793 | 0.85 | PRMT1 (0.55) | PRMT1MAPTSIRT1CYP2C9CYP2C19 | |
| SCHEMBL6078558 | 0.84 | TCF4 (0.65) | TCF4CTNNB1IDH1NPC1MAPT | |
| SCHEMBL6078726 | 0.83 | PRMT1 (0.72) | PRMT1MAPTSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20030135063-A1 | Novel naphthalene ureas as glucose uptake enhancers | SPEVAK WAYNE R (US) | 2003-07-17 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |
| WO-2000071506-A9 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030135063-A1 | Novel naphthalene ureas as glucose uptake enhancers | GPR119, SLC2A8, SLC2A1 | TCF4 1419/4885CTNNB1 2908/4885PRMT1 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.