Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.51 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077709 | 0.96 | TCF4 (0.57) | TCF4CTNNB1PRMT1IDH1NPC1 | |
| SCHEMBL6078502 | 0.93 | PRMT1 (0.58) | PRMT1SIRT1MEN1KMT2APOLB | |
| SCHEMBL6427793 | 0.88 | PRMT1 (0.55) | PRMT1MAPTSIRT1CYP2C9CYP2C19 | |
| SCHEMBL6428056 | 0.87 | PRMT1 (0.58) | PRMT1IDH1SIRT1 | |
| SCHEMBL6078536 | 0.85 | PRMT1 (0.60) | PRMT1MAPTSIRT1MEN1KMT2A | |
| SCHEMBL28327806 | 0.83 | TCF4 (0.61) | TCF4CTNNB1RAB9APOLBAKR1C3 | |
| SCHEMBL6079475 | 0.83 | PRMT1 (0.62) | PRMT1SIRT1MEN1KMT2ACYP2C9 | |
| SCHEMBL6428846 | 0.83 | PRMT1 (0.49) | PRMT1IDH1MAPTSIRT1POLB | |
| SCHEMBL6078100 | 0.82 | TCF4 (0.68) | TCF4CTNNB1IDH1NPC1RAB9A | |
| SCHEMBL6079091 | 0.82 | PRMT1 (0.64) | PRMT1SIRT1MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181271-A2 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | Telik, Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000071506-A2 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK, INC. (US) | 2000-11-30 | — | — | WO | disclosed |