Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5963296 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL5963299 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL13497212 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL5963393 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL5963394 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL13497221 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL7601504 | 0.81 | NPSR1 (0.46) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL7600152 | 0.81 | NPSR1 (0.46) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL14814142 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TRPA1NPSR1GLO1LMNA | |
| SCHEMBL5963310 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TRPA1NPSR1GLO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045619-B2 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-05-16 | — | — | US | disclosed |
| US-20030166923-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. | 2003-09-04 | — | — | US | disclosed |
| US-20020147333-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. | 2002-10-10 | — | — | US | disclosed |
| EP-0823911-A1 | ESTERS OF CARBAPENEMS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034869-A1 | ESTERS OF CARBAPENEMS | SMITHKLINE BEECHAM PLC (GB) | 1996-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147333-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | DPEP1, DHPS, JMJD6 | ALDH1A1 308/4885TRPA1 4786/4885NPSR1 4475/4885 |
| US-20030166923-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | DHPS, DPEP1, JMJD6 | ALDH1A1 343/4885TRPA1 4688/4885NPSR1 4616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.