Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079497 | 0.92 | MEN1 (0.55) | MEN1KMT2AMAPTALDH1A1CRHBP | |
| SCHEMBL6079248 | 0.91 | MEN1 (0.58) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6077690 | 0.89 | MEN1 (0.74) | MEN1KMT2A | |
| SCHEMBL6078658 | 0.87 | MEN1 (0.57) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6429403 | 0.86 | LMNA (0.62) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6079195 | 0.85 | TP53 (0.60) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6078214 | 0.85 | MEN1 (0.57) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6078607 | 0.84 | MEN1 (0.53) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6078679 | 0.83 | LMNA (0.56) | MEN1KMT2AMAPTALDH1A1CRHBP | |
| SCHEMBL6079356 | 0.82 | MEN1 (0.56) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |