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SCHEMBL6079332

SCHEMBL6079332

N#CN=C(Nc1ccc2ccc(NS(=O)(=O)c3ccc(Cl)c(C(=O)O)c3)cc2c1)Nc1ccc2ccc(NS(=O)(=O)c3ccc(Cl)c(C(=O)O)c3)cc2c1

nearest known ligand 0.70

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.53
▸ MEN1 O00255 4/20 0.53
▸ ALDH1A1 P00352 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ MIF P14174 1/20 0.46
▸ HTT P42858 1/20 0.45
▸ LMNA P02545 1/20 0.45
▸ GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6078993 0.89 ALDH1A1 (0.55) ALDH1A1LMNAGAA
SCHEMBL6079328 0.86 KMT2A (0.56) KMT2AMEN1ALDH1A1TP53MIF
SCHEMBL6079248 0.82 MEN1 (0.58) KMT2AMEN1ALDH1A1TP53
SCHEMBL6078214 0.82 MEN1 (0.57) KMT2AMEN1ALDH1A1HTTLMNA
SCHEMBL6078636 0.81 KMT2A (0.50) KMT2AMEN1ALDH1A1TP53MIF
SCHEMBL6079356 0.81 MEN1 (0.56) KMT2AMEN1ALDH1A1TP53MIF
SCHEMBL6079195 0.78 TP53 (0.60) KMT2AMEN1ALDH1A1TP53
SCHEMBL6078640 0.77 MEN1 (0.57) KMT2AMEN1ALDH1A1TP53HTT
SCHEMBL6078718 0.77 MEN1 (0.49) KMT2AMEN1ALDH1A1TP53MIF
SCHEMBL6079241 0.77 KMT2A (0.49) KMT2AMEN1ALDH1A1TP53MIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed
US-6458998-B1 NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS TELIK, INC. 2002-10-01 — — US disclosed