Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6078937 | 0.99 | POLB (0.50) | POLBF2SCN3ALMNASPHK1 | |
| SCHEMBL6078656 | 0.85 | F2 (0.47) | POLBF2LMNA | |
| SCHEMBL6077686 | 0.85 | MAOA (0.45) | POLBSCN3ALMNASPHK1CYP2C19 | |
| Hydrochloric Acid SCHEMBL6079141 | 0.84 | F2 (0.46) | POLBF2LMNA | |
| SCHEMBL6079154 | 0.83 | SCN9A (0.50) | POLBLMNACYP2C19SMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6077990 | 0.82 | SCN9A (0.49) | POLBLMNACYP2C19SMN1; SMN2CYP1A2 | |
| SCHEMBL7513994 | 0.80 | F2 (0.60) | F2KMT2A | |
| SCHEMBL6078129 | 0.80 | F2 (0.60) | F2KMT2A | |
| SCHEMBL6077640 | 0.79 | F2 (0.48) | F2LMNACYP2C19SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL6077070 | 0.79 | F2 (0.59) | F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | POLB 2995/4885F2 1/4885SCN3A 2929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.