Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6077990 | 0.99 | SCN9A (0.49) | SCN9AKCNH2GPR119POLBALDH1A1 | |
| SCHEMBL6077686 | 0.87 | MAOA (0.45) | POLBLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6078656 | 0.85 | F2 (0.47) | POLBALDH1A1LMNACYP3A4DDR1 | |
| Hydrochloric Acid SCHEMBL6079141 | 0.84 | F2 (0.46) | POLBALDH1A1LMNACYP3A4DDR1 | |
| SCHEMBL6079360 | 0.83 | POLB (0.51) | POLBSMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL6077923 | 0.82 | PTGER4 (0.38) | SCN9AKCNH2GPR119ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6078937 | 0.82 | POLB (0.50) | POLBSMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL6079352 | 0.77 | F2 (0.46) | ALDH1A1LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6078292 | 0.76 | SCN9A (0.37) | SCN9AKCNH2GPR119ALDH1A1KDM4E | |
| SCHEMBL20791371 | 0.73 | ALDH1A1 (0.63) | SCN9AALDH1A1KDM4ESMN1; SMN2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | SCN9A 1729/4885KCNH2 1427/4885GPR119 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.