Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078969 | 0.77 | ITGB3 (0.40) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL6078843 | 0.74 | ADRB2 (0.38) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL7262113 | 0.72 | CYP3A4 (0.53) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL7257470 | 0.71 | F10 (0.45) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL6079558 | 0.69 | ITGB3 (0.44) | CYP2C9CYP2D6TSHRHIF1AITGB3 | |
| SCHEMBL6080063 | 0.66 | F10 (0.44) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL14996507 | 0.63 | CYP2C9 (0.58) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL14996530 | 0.62 | CYP2C9 (0.56) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL23875490 | 0.61 | CHKA (0.59) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 | |
| SCHEMBL13131242 | 0.61 | ADRB2 (0.58) | CYP2C9CYP2D6TSHRCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122662-B2 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| US-20050148769-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6858599-B2 | Inhibitor for activated blood coagulation factor X | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| US-20040063716-A1 | Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-20030045520-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063716-A1 | Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds | VKORC1, CYP46A1, TFPI | CYP2C9 139/4885CYP2D6 301/4885TSHR 2844/4885 |
| US-20030045520-A1 | Tricyclic compound having spiro union | F2, TFPI, F11 | CYP2C9 194/4885CYP2D6 627/4885TSHR 1480/4885 |
| US-20050148769-A1 | Tricyclic compound having spiro union | TFPI, F2, F12 | CYP2C9 194/4885CYP2D6 621/4885TSHR 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.