Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079127 | 0.88 | PRMT1 (0.58) | MEN1KMT2AGAAPRMT1SIRT1 | |
| SCHEMBL6078794 | 0.84 | MEN1 (0.60) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL6078536 | 0.82 | PRMT1 (0.60) | MEN1KMT2AGAAPRMT1SIRT1 | |
| SCHEMBL6428056 | 0.81 | PRMT1 (0.58) | PRMT1SIRT1KDM4EALDH1A1 | |
| SCHEMBL6077709 | 0.81 | TCF4 (0.57) | MEN1KMT2APRMT1SIRT1LMNA | |
| SCHEMBL7663909 | 0.80 | PLAU (0.66) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL6077806 | 0.80 | PRMT1 (0.54) | MEN1KMT2APRMT1SIRT1LMNA | |
| SCHEMBL6078550 | 0.79 | PRMT1 (0.68) | MEN1KMT2AGAAPRMT1SIRT1 | |
| SCHEMBL6427793 | 0.79 | PRMT1 (0.55) | GAAPRMT1SIRT1SMN1; SMN2HTT | |
| SCHEMBL7520951 | 0.78 | TCF4 (0.53) | MEN1KMT2APRMT1SIRT1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |