Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | OGT | O15294 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077873 | 0.91 | TSHR (0.59) | LMNAALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL6079548 | 0.87 | ALDH1A1 (0.59) | LMNAALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL6078420 | 0.86 | PLAU (0.50) | LMNAALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL6078277 | 0.86 | LMNA (0.67) | LMNAALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL7966502 | 0.84 | ALDH1A1 (0.67) | ALDH1A1GAAMEN1KMT2APLAU | |
| SCHEMBL6429403 | 0.83 | LMNA (0.62) | LMNAALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL6078687 | 0.82 | CYP2C9 (0.65) | LMNAALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL6078109 | 0.82 | PLAU (0.72) | LMNAALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL12041052 | 0.81 | MEN1 (0.65) | LMNAALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL6078794 | 0.81 | MEN1 (0.60) | LMNAALDH1A1GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |