SCHEMBL608146

SCHEMBL608146

Nc1nc2c(ncn2[C@@H]2O[C@H](CS)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HINT1 P49773 6/20 0.67
▸ NT5E P21589 1/20 0.67
▸ GSK3A P49840 2/20 0.62
▸ RPS6KA3 P51812 2/20 0.62
▸ MAPK14 Q16539 2/20 0.62
▸ HPGD P15428 1/20 0.62
▸ TGM2 P21980 1/20 0.61
▸ PNP P00491 1/20 0.60
▸ STING1 Q86WV6 2/20 0.58
▸ PDE3B Q13370 1/20 0.58
▸ PDE3A Q14432 1/20 0.58
▸ KRAS P01116 3/20 0.56
▸ FUT5 Q11128 1/20 0.55
▸ TAAR1 Q96RJ0 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL11084574 0.95 HINT1 (0.67) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL5550180 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL20750695 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL278157 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL24049467 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL24049417 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL24049608 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL24049416 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL16114035 0.90 HINT1 (0.68) HINT1NT5EGSK3ARPS6KA3MAPK14
Guanosine SCHEMBL7062800 0.90 HPGD (0.76) HINT1NT5EGSK3ARPS6KA3MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 914 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119866224-A Polynucleotide encoding a linking antigen and uses thereof 加拿大干细胞技术公司 2025-04-22 — — CN claimed
CN-119317430-A Lipid nanoparticles comprising Venezuelan Equine Encephalitis (VEE) replicons and uses thereof 斯特兰德生物科技公司 2025-01-14 — — CN claimed
WO-2024129779-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-06-20 — — WO claimed
WO-2023212618-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF STRAND THERAPEUTICS INC. (US) 2023-11-02 — — WO claimed
CN-116916936-A Compositions and methods for delivering RNA 再生技术有限责任公司 2023-10-20 — — CN claimed
US-20230126310-A1 COMPOSITIONS FOR CORONAVIRUS INFECTION TREATMENT AND/OR PREVENTION FRAUNHOFER GES FORSCHUNG (DE) 2023-04-27 — — US claimed
EP-4126234-A1 COMPOSITIONS FOR CORONAVIRUS INFECTION TREATMENT AND/OR PREVENTION Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2023-02-08 — — EP claimed
CN-115474430-A Composition for treatment and/or prevention of coronavirus infection 弗劳恩霍夫应用研究促进协会 2022-12-13 — — CN claimed
US-20220154222-A1 NOVEL NUCLEIC ACID MODIFIERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2022-05-19 — — US claimed
EP-3964206-A1 COMPOUNDS FOR THE TREATMENT OF COVID-19 Dompe' Farmaceutici S.P.A. (IT) 2022-03-09 — — EP claimed
US-20110287412-A1 Methods for Identifying RNA Segments Bound by RNA-Binding Proteins or Ribonucleoprotein Complexes ROCKEFELLER UNIVERSITY (US) 2011-11-24 — — US claimed
US-20100285001-A1 Method and Compositions Related to Synergistic Responses to Oncogenic Mutations UNIVERSITY OF ROCHESTER (US) 2010-11-11 — — US claimed
EP-2188630-A2 METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONS THE UNIVERSITY OF ROCHESTER (US) 2010-05-26 — — EP claimed
WO-2010014636-A1 METHODS FOR IDENTIFYING RNA SEGMENTS BOUND BY RNA-BINDING PROTEINS OR RIBONUCLEOPROTEIN COMPLEXES ROCKEFELLER UNIVERSITY (US) 2010-02-04 — — WO claimed
WO-2009045443-A2 METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONS THE UNIVERSITY OF ROCHESTER (US) 2009-04-09 — — WO claimed
US-20090042947-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS CONTAINING SULFUR JON PTY LIMITED (AU) 2009-02-12 — — US claimed
WO-2008125903-A2 METHOD OF INHIBITING AN UNDESIRED IMMUNE RESPONSE CHAIM SHEBA MEDICAL CENTER (US) 2008-10-23 — — WO claimed
EP-1907407-A1 IMPROVEMENTS TO ANALOGOUS COMPOUNDS OF 6-THIOGUANOSINE TRIPHOSPHATE, THEIR USE IN MEDICAL FIELDS AND PROCESSES FOR THEIR PREPARATION Giuliani International Limited (IE) 2008-04-09 — — EP claimed
WO-2007056817-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS CONTAINING SULFUR JON PTY LIMITED (AU) 2007-05-24 — — WO claimed
WO-2007010515-A1 IMPROVEMENTS TO ANALOGOUS COMPOUNDS OF 6-THIOGUANOSINE TRIPHOSPHATE, THEIR USE IN MEDICAL FIELDS AND PROCESSES FOR THEIR PREPARATION GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042947-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS CONTAINING SULFUR SCLY, STS, SQOR HINT1 1801/4885NT5E 4363/4885GSK3A 4508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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