Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6082947 | 0.88 | DRD4 (0.57) | DRD2DRD4DRD3 | |
| SCHEMBL6081769 | 0.88 | ALDH1A1 (0.46) | HTR1AADRA1DADRA1BADRA1ADRD2 | |
| SCHEMBL1727502 | 0.85 | MAOB (0.48) | — | |
| SCHEMBL1728648 | 0.84 | HTT (0.49) | HTR1AADRA1DADRA1BADRA1AMEN1 | |
| SCHEMBL6081506 | 0.84 | ALDH1A1 (0.46) | MEN1KMT2A | |
| SCHEMBL1728589 | 0.82 | DRD2 (0.53) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6080989 | 0.82 | DRD2 (0.50) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1729079 | 0.81 | GAA (0.62) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6081354 | 0.81 | DRD2 (0.56) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1729303 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |