Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 10/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081674 | 0.84 | HTR1A (0.45) | MEN1KMT2AHTR1AADRA1DADRA1A | |
| SCHEMBL6082947 | 0.82 | DRD4 (0.57) | — | |
| SCHEMBL6081506 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2AHPGDSMN1; SMN2TDP1 | |
| SCHEMBL6081769 | 0.78 | ALDH1A1 (0.46) | L3MBTL1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL1729303 | 0.77 | ALDH1A1 (0.51) | MEN1KMT2AHPGDSMN1; SMN2TDP1 | |
| SCHEMBL1728589 | 0.77 | DRD2 (0.53) | MEN1LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1729079 | 0.76 | GAA (0.62) | MEN1KMT2A | |
| SCHEMBL6081354 | 0.76 | DRD2 (0.56) | MEN1LMNAKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL1727502 | 0.76 | MAOB (0.48) | — | |
| SCHEMBL13499480 | 0.75 | HPGD (0.42) | HTTMEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |