Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728493 | 0.84 | MCHR1 (0.78) | MCHR1KCNH2LTA4HFGFR1SRC | |
| SCHEMBL1728515 | 0.84 | MCHR1 (0.52) | MCHR1KCNH2MAPK14LTA4HCYP1A2 | |
| SCHEMBL6082151 | 0.82 | MCHR1 (0.60) | MCHR1KCNH2MAPK14LTA4HCYP1A2 | |
| SCHEMBL1728669 | 0.82 | LTA4H (0.68) | MCHR1KCNH2MAPK14LTA4HCYP1A2 | |
| SCHEMBL1728477 | 0.81 | MCHR1 (0.56) | MCHR1KCNH2MAPK14MAPTCYP1A2 | |
| SCHEMBL1728621 | 0.81 | MCHR1 (0.63) | MCHR1KCNH2MAPK14MAOBMAPT | |
| SCHEMBL6080985 | 0.80 | MCHR1 (0.54) | MCHR1MAPK14LTA4HCYP1A2CYP2D6 | |
| SCHEMBL6081903 | 0.80 | MCHR1 (0.54) | MCHR1KCNH2MAPK14LTA4HCYP1A2 | |
| SCHEMBL6081522 | 0.80 | ALDH1A1 (0.55) | MCHR1KCNH2MAPK14MAPTLTA4H | |
| SCHEMBL1728658 | 0.80 | LTA4H (0.70) | MCHR1KCNH2LTA4HCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |