Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822466 | 1.00 | IDO1 (0.35) | IDO1NR1I2SOS1CCNT1CDK9 | |
| SCHEMBL6817840 | 0.89 | CRHR1 (0.39) | IDO1NR1I2SOS1CRHR1 | |
| SCHEMBL6082133 | 0.89 | CRHR1 (0.39) | IDO1NR1I2SOS1CRHR1 | |
| SCHEMBL6084266 | 0.88 | IDO1 (0.35) | IDO1SOS1 | |
| SCHEMBL6082688 | 0.84 | IDO1 (0.35) | IDO1NR1I2SOS1CCNT1CDK9 | |
| SCHEMBL6081913 | 0.84 | IDO1 (0.35) | IDO1NR1I2SOS1CCNT1CDK9 | |
| SCHEMBL6082536 | 0.82 | IDO1 (0.35) | IDO1 | |
| SCHEMBL6082363 | 0.82 | PIK3CA (0.37) | CRHR1 | |
| SCHEMBL6822467 | 0.77 | KMT5A (0.34) | CCNT1CDK9 | |
| SCHEMBL6817773 | 0.76 | CRHR1 (0.39) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067658-B2 | Pyridino and pyrimidino pyrazinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| US-20040082784-A1 | Pyridino and pyrimidino pyrazinones | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082784-A1 | Pyridino and pyrimidino pyrazinones | CRHR1, CRHR2, CRH | IDO1 667/4885NR1I2 103/4885SOS1 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.