Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | XDH | P47989 | 1/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.50 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513175 | 0.88 | KMT2A (1.00) | KMT2AXDHFLT3CYP1A2CYP2C9 | |
| SCHEMBL31060195 | 0.84 | FLT3 (1.00) | KMT2AXDHFLT3PDGFRBPDGFRA | |
| SCHEMBL6300554 | 0.82 | XDH (0.74) | KMT2AXDHFLT3MEN1PDGFRB | |
| SCHEMBL2729934 | 0.81 | PDGFRB (0.79) | KMT2AFLT3CYP1A2CYP2C9MEN1 | |
| SCHEMBL13133298 | 0.81 | KDM4E (0.81) | KMT2AFLT3CYP1A2CYP2C9MEN1 | |
| SCHEMBL8870075 | 0.79 | KMT2A (0.78) | KMT2AXDHFLT3CYP1A2CYP2C9 | |
| SCHEMBL8869244 | 0.79 | KMT2A (0.78) | KMT2AXDHFLT3CYP1A2CYP2C9 | |
| SCHEMBL10004477 | 0.79 | KMT2A (0.67) | KMT2AXDHFLT3CYP1A2CYP2C9 | |
| SCHEMBL10084366 | 0.77 | IDO1 (0.54) | KMT2AXDHFLT3CYP1A2CYP2C9 | |
| SCHEMBL9816551 | 0.77 | KMT2A (0.78) | KMT2AXDHFLT3CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | disclosed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | FLT1, FLT4, VEGFA | KMT2A 3789/4885XDH 151/4885FLT3 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.