Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP14 | P50281 | 2/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700465 | 0.87 | KDM4E (0.66) | IDO1ABCB1PDGFRBPDGFRAPIN1 | |
| SCHEMBL22777743 | 0.87 | KDM4E (0.66) | IDO1ABCB1PDGFRBPDGFRAPIN1 | |
| SCHEMBL419130 | 0.80 | MMP13 (0.77) | IDO1MMP2MMP13MMP14MAPT | |
| SCHEMBL68771 | 0.79 | FLT3 (0.71) | IDO1PDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL6087009 | 0.77 | KMT2A (0.78) | PDGFRBPDGFRAKDM4EHPGDSRD5A2 | |
| SCHEMBL2732420 | 0.76 | FLT3 (0.73) | PDGFRBPDGFRASMAD3FLT3 | |
| SCHEMBL10242689 | 0.76 | PIN1 (0.74) | IDO1PDGFRBPDGFRAPIN1KDM4E | |
| SCHEMBL15223730 | 0.76 | HRH4 (0.62) | PDGFRBPDGFRAMMP2MMP13PIN1 | |
| SCHEMBL20067066 | 0.76 | MAPT (0.45) | PDGFRBPDGFRAPIN1MAPTKDM4E | |
| SCHEMBL3640332 | 0.75 | SMAD3 (0.69) | PDGFRBPDGFRAPIN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012051708-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES, AND METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-04-26 | — | — | WO | disclosed |