Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
| ▸ | MGAM | O43451 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | SI | P14410 | 4/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086702 | 0.95 | MGAM (0.56) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL6087461 | 0.92 | ALOX5 (0.56) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL1359809 | 0.88 | ALOX5 (0.51) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL6088211 | 0.87 | MCL1 (0.50) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL6086405 | 0.86 | LMNA (0.54) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL4966110 | 0.85 | MGAM (0.53) | NPSR1MAPTMAPK1NOD2MGAM | |
| SCHEMBL6087007 | 0.85 | MCL1 (0.53) | NPSR1MAPTMGAMGAASI | |
| SCHEMBL6668074 | 0.84 | MAOB (0.54) | NPSR1MAPTMAPK1NOD2ALOX5 | |
| SCHEMBL6088276 | 0.83 | SMN1; SMN2 (0.49) | MAPTMAPK1GAABACE1ALDH1A1 | |
| SCHEMBL6086911 | 0.80 | ESR2 (0.54) | MAPTMAPK1NOD2GAABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045628-B2 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | ELI LILLY AND COMPANY (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040133047-A1 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | MAY SCOTT ALLAN (US) | 2004-07-08 | — | — | US | disclosed |
| WO-2002044119-A2 | SYNTHESIS OF 2-ARYL-1-NAPHTHOL DERIVATIVES VIA A TANDEM PALLADIUM CATALYZED ARYLATION AND DEHYDROGENATION | ELI LILLY AND COMPANY (US) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133047-A1 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | NQO1, CYP1A1, DDT | NPSR1 1042/4885MAPT 3361/4885MAPK1 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.