Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | F9 | P00740 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087375 | 0.84 | NPSR1 (0.58) | MAOBMAPTNPSR1MAPK1NOD2 | |
| SCHEMBL225278 | 0.82 | MAOB (0.61) | MAOBMAPTNPSR1MAPK1NOD2 | |
| SCHEMBL6086702 | 0.81 | MGAM (0.56) | MAOBMAPTNPSR1MAPK1NOD2 | |
| SCHEMBL5268433 | 0.80 | MAOB (0.49) | MAOBP2RY14ALOX5FFAR1DYRK1B | |
| SCHEMBL6667573 | 0.80 | HSD17B1 (0.52) | MAPK1NOD2 | |
| SCHEMBL9405631 | 0.79 | MAOB (0.71) | MAOBPPARDGSTP1FFAR1F9 | |
| SCHEMBL6672286 | 0.77 | BACE1 (0.53) | BCHE | |
| SCHEMBL4966110 | 0.77 | MGAM (0.53) | MAOBMAPTNPSR1MAPK1NOD2 | |
| SCHEMBL7096339 | 0.77 | L3MBTL1 (0.57) | MAOBNPSR1F9F10DYRK1B | |
| SCHEMBL6671006 | 0.77 | MTNR1A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838459-B1 | Naphthyl compounds, compositions, and methods | LILLY CO ELI (US) | 2004-09-22 | — | — | EP | disclosed |
| US-5952350-A | INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, AND CARDIOVASCULAR DISORDERS INCLUDING HYPERLIPIDEMIA, AND ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0838459-A1 | Naphthyl compounds, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-29 | — | — | EP | disclosed |