Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217699 | 0.92 | SLC6A4 (0.56) | IDO1SLC6A4IKBKBGPR84HTR2A | |
| SCHEMBL6087543 | 0.89 | IDO1 (0.56) | IDO1SLC6A4IKBKB | |
| SCHEMBL6088540 | 0.83 | IKBKB (0.44) | IDO1SLC6A4IKBKBHTR2AHTR1D | |
| SCHEMBL6090803 | 0.83 | IDO1 (0.56) | IDO1SLC6A4HTR2AHTR1BHTR1A | |
| SCHEMBL6088026 | 0.83 | IDO1 (0.56) | IDO1SLC6A4HTR2AHTR1BHTR1A | |
| SCHEMBL3886137 | 0.83 | IDO1 (0.56) | IDO1SLC6A4HTR2AHTR1BHTR1A | |
| SCHEMBL6087784 | 0.83 | IDO1 (0.56) | IDO1SLC6A4IKBKBGPR84HTR2A | |
| SCHEMBL20740534 | 0.82 | SLC6A4 (0.69) | IDO1SLC6A4GPR84HTR2ATRPM8 | |
| SCHEMBL6087602 | 0.80 | SLC6A4 (0.60) | IDO1SLC6A4HTR2AHTR1BHTR1A | |
| SCHEMBL6086690 | 0.80 | SLC6A4 (0.60) | IDO1SLC6A4HTR2AHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049314-B2 | Sexual disorders; antidepressants; attention deficit hyperactivity, obsessive-compulsive, and/or post-traumatic stress disorder; drug abuse and addiction | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-20040077705-A1 | Cyclopentyl indole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
| WO-2004026236-A2 | CYCLOPENTYL INDOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077705-A1 | Cyclopentyl indole derivatives | HTR5A, TPH1, TPH2 | IDO1 25/4885SLC6A4 11/4885IKBKB 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.