Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088650 | 0.91 | NR4A2 (0.41) | NPC1NR4A2RAB9ACYSLTR1GPBAR1 | |
| SCHEMBL6089203 | 0.86 | CYSLTR1 (0.50) | CYSLTR1GPBAR1ALOX5CYSLTR2 | |
| SCHEMBL6088343 | 0.79 | MAPT (0.41) | NPC1RAB9ACYSLTR1GPBAR1MAPT | |
| SCHEMBL6087611 | 0.78 | ALOX5 (0.36) | NPC1NR4A2RAB9ACYSLTR1MAPT | |
| SCHEMBL6088319 | 0.77 | MAPT (0.43) | CYSLTR1GPBAR1MAPTTP53CYSLTR2 | |
| SCHEMBL6090684 | 0.77 | NR4A2 (0.46) | NPC1NR4A2RAB9ACYSLTR1GPBAR1 | |
| SCHEMBL6089097 | 0.76 | FFAR1 (0.45) | NR4A2MRGPRX4SMN1; SMN2 | |
| SCHEMBL6087968 | 0.76 | CYSLTR1 (0.56) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6087715 | 0.75 | CYSLTR1 (0.40) | NPC1NR4A2RAB9ACYSLTR1GPBAR1 | |
| SCHEMBL6089044 | 0.75 | DHODH (0.38) | CYSLTR1GPBAR1MAPTTP53ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |