Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTH | P32929 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549787 | 1.00 | CTH (0.49) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8429877 | 0.89 | CTH (0.43) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8425570 | 0.84 | CTH (0.45) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL7204462 | 0.83 | ALDH1A1 (0.37) | CTHALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL13140460 | 0.82 | CTH (0.49) | CTHALDH1A1KMT2AHTT | |
| SCHEMBL13140454 | 0.82 | CTH (0.49) | CTHALDH1A1KMT2AHTT | |
| SCHEMBL28115995 | 0.81 | ALDH1A1 (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8977676 | 0.81 | ALDH1A1 (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8429735 | 0.80 | CTH (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL16361273 | 0.80 | KMT2A (0.60) | CTHALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109223-B2 | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma | MERCK & CO. INC. (US) | 2006-09-19 | — | — | US | disclosed |