Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTH | P32929 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087635 | 1.00 | CTH (0.49) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8429877 | 0.89 | CTH (0.43) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8425570 | 0.84 | CTH (0.45) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL7204462 | 0.83 | ALDH1A1 (0.37) | CTHALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL13140460 | 0.82 | CTH (0.49) | CTHALDH1A1KMT2AHTT | |
| SCHEMBL13140454 | 0.82 | CTH (0.49) | CTHALDH1A1KMT2AHTT | |
| SCHEMBL28115995 | 0.81 | ALDH1A1 (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8977676 | 0.81 | ALDH1A1 (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8429735 | 0.80 | CTH (0.42) | CTHALDH1A1KMT2AMEN1PKM | |
| SCHEMBL16361273 | 0.80 | KMT2A (0.60) | CTHALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555803-B1 | PROCESS FOR PREPARING HYPERPOLARIZED SUBSTRATES AND METHOD FOR MRI | BRACCO IMAGING SPA (IT) | 2018-09-12 | — | — | EP | claimed |
| EP-2766050-B1 | PROCESS FOR THE PREPARATION OF HYPERPOLARIZED DERIVATIVES FOR USE IN MRI ANALYSIS | BRACCO IMAGING SPA (IT) | 2018-09-05 | — | — | EP | claimed |
| US-9694090-B2 | Process for preparing hyperpolarized substrates and method for MRI | BRACCO IMAGING S.P.A. (IT) | 2017-07-04 | — | — | US | claimed |
| US-9511154-B2 | Process for the preparation of hyperpolarized derivatives for use in MRI analysis | BRACCO IMAGING S.P.A. (IT) | 2016-12-06 | — | — | US | claimed |
| CN-102892434-B | Method for preparing hyperpolarized substrates and MRI method | BRACCO IMAGING SPA | 2014-11-19 | — | — | CN | claimed |
| US-20140257085-A1 | Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis | BRACCO IMAGING S.P.A. (IT) | 2014-09-11 | — | — | US | claimed |
| EP-2766050-A1 | PROCESS FOR THE PREPARATION OF HYPERPOLARIZED DERIVATIVES FOR USE IN MRI ANALYSIS | Bracco Imaging S.p.A (IT) | 2014-08-20 | — | — | EP | claimed |
| US-20130096420-A1 | Process For Preparing Hyperpolarized Substrates And Method For MRI | BRACCO IMAGING S.P.A. (IT) | 2013-04-18 | — | — | US | claimed |
| WO-2013053839-A1 | PROCESS FOR THE PREPARATION OF HYPERPOLARIZED DERIVATIVES FOR USE IN MRI ANALYSIS | BRACCO IMAGING SPA (IT) | 2013-04-18 | — | — | WO | claimed |
| EP-2555803-A1 | PROCESS FOR PREPARING HYPERPOLARIZED SUBSTRATES AND METHOD FOR MRI | Bracco Imaging S.p.A (IT) | 2013-02-13 | — | — | EP | claimed |
| CN-102892434-A | Method for preparing hyperpolarized substrates and MRI method | BRACCO IMAGING SPA | 2013-01-23 | — | — | CN | claimed |
| WO-2011124672-A1 | PROCESS FOR PREPARING HYPERPOLARIZED SUBSTRATES AND METHOD FOR MRI | BRACCO IMAGING SPA (IT) | 2011-10-13 | — | — | WO | claimed |
| EP-2555803-B1 | PROCESS FOR PREPARING HYPERPOLARIZED SUBSTRATES AND METHOD FOR MRI | BRACCO IMAGING SPA (IT) | 2018-09-12 | — | — | EP | disclosed |
| EP-2766050-B1 | PROCESS FOR THE PREPARATION OF HYPERPOLARIZED DERIVATIVES FOR USE IN MRI ANALYSIS | BRACCO IMAGING SPA (IT) | 2018-09-05 | — | — | EP | disclosed |
| US-9694090-B2 | Process for preparing hyperpolarized substrates and method for MRI | BRACCO IMAGING S.P.A. (IT) | 2017-07-04 | — | — | US | disclosed |
| US-9694090-B2 | Process for preparing hyperpolarized substrates and method for MRI | BRACCO IMAGING S.P.A. (IT) | 2017-07-04 | — | — | US | disclosed |
| EP-0583863-B1 | Use of esters of L-2-oxothiazolidine-4-carboxylate for the manufacture of a medicament for stimulating intracellar synthesis of glutathione | TRANSCEND THERAPEUTICS INC (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0583863-A1 | Use of esters of L-2-oxothiazolidine-4-carboxylate for the manufacture of a medicament for stimulating intracellar synthesis of glutathione | Transcend Therapeutics, Inc. (US) | 1994-02-23 | — | — | EP | disclosed |
| US-5208249-A | Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate | CLINTEC NUTRITION CO. (US) | 1993-05-04 | — | — | US | disclosed |
| US-4042595-A | Processes for the production of heterocyclic compounds | SNAM PROGETTI S.P.A. (IT) | 1977-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140257085-A1 | Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis | CA4, SLC16A3, SLC16A1 | CTH 637/4885ALDH1A1 733/4885KMT2A 1781/4885 |
| US-20130096420-A1 | Process For Preparing Hyperpolarized Substrates And Method For MRI | HOGA1, HAMP, GLS2 | CTH 651/4885ALDH1A1 1420/4885KMT2A 3312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.