Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 12/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | LTA4H | P09960 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10497217 | 0.96 | HDAC6 (0.71) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1065527 | 0.94 | HDAC6 (0.74) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1433994 | 0.94 | HDAC6 (0.74) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL6296181 | 0.92 | HDAC4 (0.75) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL3353284 | 0.90 | L3MBTL1 (0.72) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| Trifluoroacetic Acid SCHEMBL3202548 | 0.90 | HDAC4 (0.66) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| Hydrochloric Acid SCHEMBL3353961 | 0.89 | L3MBTL1 (0.70) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL517309 | 0.88 | HDAC4 (0.81) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL29266758 | 0.87 | SOAT2 (0.74) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL3806017 | 0.86 | MEN1 (0.73) | HDAC4HDAC1HDAC7HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106000465-A | Method for oxidative coupling reaction of aldehyde and secondary amide | 苏州大学 | 2016-10-12 | — | — | CN | claimed |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | CEPHALON, INC. (US) | 2011-06-16 | — | — | US | claimed |
| US-7915236-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2011-03-29 | — | — | US | claimed |
| EP-1660507-B9 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-03-24 | — | — | EP | claimed |
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2009-11-26 | — | — | US | claimed |
| EP-1660507-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-08-05 | — | — | EP | claimed |
| CN-1867572-A | proteasome inhibitors and methods of use thereof | CEPHALON INC (US) | 2006-11-22 | — | — | CN | claimed |
| EP-1660507-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2006-05-31 | — | — | EP | claimed |
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-19 | — | — | US | claimed |
| WO-2005021558-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2005-03-10 | — | — | WO | claimed |
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |
| EP-0666848-B1 | SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE | BASF AG (DE) | 1998-12-30 | — | — | EP | claimed |
| US-5698494-A | Substituted N-phenylglutarimides and N-phenylglutaramides, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-16 | — | — | US | claimed |
| EP-0666848-A1 | SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE | BASF Aktiengesellschaft (DE) | 1995-08-16 | — | — | EP | claimed |
| WO-1994010147-A1 | SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE | BASF AKTIENGESELLSCHAFT (DE) | 1994-05-11 | — | — | WO | claimed |
| EP-1660507-B2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | MILLENNIUM PHARM INC (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-0666848-A1 | SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE | BASF Aktiengesellschaft (DE) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010147-A1 | SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE | BASF AKTIENGESELLSCHAFT (DE) | 1994-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | PSMB11, PSMB5, PSMB6 | HDAC4 271/4885HDAC1 249/4885HDAC7 275/4885 |
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | HDAC4 271/4885HDAC1 249/4885HDAC7 275/4885 |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | PSMB11, PSMB5, PSMB6 | HDAC4 271/4885HDAC1 249/4885HDAC7 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.