Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 17/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 17/20 | 0.74 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.74 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | BRD4 | O60885 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | LTA4H | P09960 | 1/20 | 0.74 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065527 | 1.00 | HDAC6 (0.74) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL10497217 | 0.98 | HDAC6 (0.71) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL608911 | 0.94 | HDAC4 (0.66) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| Hydroxyamine SCHEMBL1268824 | 0.92 | HDAC6 (0.79) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL6669511 | 0.92 | HDAC4 (0.85) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL137348 | 0.92 | HDAC4 (0.85) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL6665592 | 0.92 | HDAC4 (0.85) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL1065393 | 0.92 | HDAC4 (0.85) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL29266758 | 0.92 | SOAT2 (0.74) | HDAC6HDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL517309 | 0.90 | HDAC4 (0.81) | HDAC6HDAC4HDAC1HDAC7HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651199-B | Histone deacetylase and microtubule double-target inhibitor and preparation method thereof | 青岛大学 | 2022-01-04 | — | — | CN | claimed |
| EP-3407913-A1 | USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES | Indiana University Research & Technology Corporation (US) | 2018-12-05 | — | — | EP | claimed |
| WO-2018160676-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT HIV-1 INFECTIONS | UNIVERSITY OF THE SCIENCES (US) | 2018-09-07 | — | — | WO | claimed |
| WO-2017132536-A1 | USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2017-08-03 | — | — | WO | claimed |
| US-9693994-B2 | Class IIa HDAC inhibitors for the treatment of infection | RESEARCH DEVELOPMENT FOUNDATION (US) | 2017-07-04 | — | — | US | claimed |
| WO-2015157500-A1 | CLASS IIA HDAC INHIBITORS FOR THE TREATMENT OF INFECTION | RESEARCH DEVELOPMENT FOUNDATION (US) | 2015-10-15 | — | — | WO | claimed |
| WO-2013022715-A2 | PBAP48 TRANSGENIC MICE FOR DRUG DISCOVERY IN AGE-RELATED MEMORY DECLINE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-02-14 | — | — | WO | claimed |
| EP-2544673-A1 | THIOXANTHONE-BASED AUTOPHAGY INHIBITOR THERAPIES TO TREAT CANCER | Spectrum Pharmaceuticals, Inc. (US) | 2013-01-16 | — | — | EP | claimed |
| WO-2012162535-A1 | USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-11-29 | — | — | WO | claimed |
| WO-2011112623-A1 | THIOXANTHONE-BASED AUTOPHAGY INHIBITOR THERAPIES TO TREAT CANCER | SPECTRUM PHARMACEUTICALS, INC. (US) | 2011-09-15 | — | — | WO | claimed |
| WO-2011061545-A1 | HPLC METHOD FOR ANALYZING VORINOSTAT | GENERICS [UK] LIMITED (GB) | 2011-05-26 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2024263963-A2 | COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING HEAD AND NECK CANCER | BURZYNSKI STANISLAW R (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2024263972-A2 | COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING UNCOMMON CANCERS | BURZYNSKI STANISLAW R (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2024263804-A2 | COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING KIDNEY CANCER | BURZYNSKI STANISLAW R (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2024263798-A1 | COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING PROSTATE CANCER | BURZYNSKI STANISLAW R (US) | 2024-12-26 | — | — | WO | disclosed |
| US-20070100559-A1 | Crystal structure of a deacetylase and inhibitors thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2007-05-03 | — | — | US | disclosed |
| US-20070100559-A1 | Crystal structure of a deacetylase and inhibitors thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2007-05-03 | — | — | US | disclosed |
| US-20070087427-A1 | Crystal structure of a deacetylase and inhibitors thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2007-04-19 | — | — | US | disclosed |
| US-20070087427-A1 | Crystal structure of a deacetylase and inhibitors thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2007-04-19 | — | — | US | disclosed |