Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089176 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6091976 | 0.91 | JAK2 (0.38) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6091985 | 0.91 | JAK2 (0.38) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6089552 | 0.90 | JAK2 (0.40) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6089558 | 0.90 | JAK2 (0.40) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6090981 | 0.82 | ALOX5 (0.46) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6090979 | 0.82 | ALOX5 (0.46) | SMN1; SMN2MAPTABL1RETPDGFRB | |
| SCHEMBL6090324 | 0.80 | MAPT (0.38) | SMN1; SMN2MAPTGABRA1GABRB1GABRA3 | |
| SCHEMBL6090321 | 0.80 | MAPT (0.38) | SMN1; SMN2MAPTGABRA1GABRB1GABRA3 | |
| SCHEMBL6091072 | 0.79 | ABL1 (0.39) | SMN1; SMN2MAPTABL1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |