Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089558 | 1.00 | JAK2 (0.40) | JAK2JAK3GABRA1GABRB2ABL1 | |
| SCHEMBL6091985 | 0.91 | JAK2 (0.38) | JAK2JAK3GABRA1GABRB2ABL1 | |
| SCHEMBL6091976 | 0.91 | JAK2 (0.38) | JAK2JAK3GABRA1GABRB2ABL1 | |
| SCHEMBL6089176 | 0.90 | SMN1; SMN2 (0.42) | JAK2JAK3GABRA1GABRB2ABL1 | |
| SCHEMBL6089181 | 0.90 | SMN1; SMN2 (0.42) | JAK2JAK3GABRA1GABRB2ABL1 | |
| SCHEMBL6088802 | 0.84 | ABL1 (0.54) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6090270 | 0.81 | LMNA (0.40) | JAK2JAK3GABRA1GABRB2LMNA | |
| SCHEMBL6090279 | 0.81 | LMNA (0.40) | JAK2JAK3GABRA1GABRB2LMNA | |
| SCHEMBL6089849 | 0.81 | HTR6 (0.41) | GABRA1GABRB2ABL1RETPDGFRB | |
| SCHEMBL6089845 | 0.81 | HTR6 (0.41) | GABRA1GABRB2ABL1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |