Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090321 | 1.00 | MAPT (0.38) | MAPTSMN1; SMN2TSHRKDREP300 | |
| SCHEMBL6091331 | 0.91 | CA12 (0.39) | MAPTSMN1; SMN2KDRGABRA1GABRB2 | |
| SCHEMBL6091332 | 0.91 | CA12 (0.39) | MAPTSMN1; SMN2KDRGABRA1GABRB2 | |
| SCHEMBL6090270 | 0.90 | LMNA (0.40) | MAPTSMN1; SMN2TSHRKDRPTPN1 | |
| SCHEMBL6090279 | 0.90 | LMNA (0.40) | MAPTSMN1; SMN2TSHRKDRPTPN1 | |
| SCHEMBL6089176 | 0.80 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2TSHRKDRGABRA1 | |
| SCHEMBL6089181 | 0.80 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2TSHRKDRGABRA1 | |
| SCHEMBL6089458 | 0.78 | JMJD6 (0.35) | SMN1; SMN2KDREP300KAT8GABRA1 | |
| SCHEMBL6089465 | 0.78 | JMJD6 (0.35) | SMN1; SMN2KDREP300KAT8GABRA1 | |
| SCHEMBL6090481 | 0.78 | DAO (0.35) | KDRPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |