Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089639 | 0.87 | CYSLTR1 (0.41) | CYP1A2SIRT2CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6088877 | 0.82 | CYP1A2 (0.36) | CYP1A2CYSLTR1CYSLTR2KDM4EALDH1A1 | |
| SCHEMBL6088757 | 0.74 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6089331 | 0.72 | CYSLTR1 (0.36) | CYP1A2CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6089021 | 0.72 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6089420 | 0.71 | CYSLTR1 (0.47) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6090963 | 0.70 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL4848377 | 0.69 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1ALOX5AP | |
| SCHEMBL4844970 | 0.69 | CYSLTR1 (0.50) | CYP1A2CYSLTR1CYSLTR2ALDH1A1GPBAR1 | |
| SCHEMBL6089628 | 0.69 | CYSLTR1 (0.37) | CYP1A2SIRT2CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |