Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088264 | 0.89 | PDE3B (0.32) | DAO | |
| SCHEMBL6092889 | 0.82 | KDR (0.34) | GPR84KDRUSP2MAPTALOX15 | |
| SCHEMBL6092890 | 0.82 | KDR (0.34) | GPR84KDRUSP2MAPTALOX15 | |
| SCHEMBL6091447 | 0.77 | PDPK1 (0.47) | KDRMAPTMAPK1ALDH1A1 | |
| SCHEMBL6089196 | 0.75 | SIRT1 (0.46) | KDRMAPTMAPK1RAB9ACYP1A2 | |
| SCHEMBL6089199 | 0.75 | SIRT1 (0.46) | KDRMAPTMAPK1RAB9ACYP1A2 | |
| SCHEMBL6090485 | 0.73 | DAO (0.35) | GPR84KDRDAOALDH1A1 | |
| SCHEMBL6089383 | 0.73 | TUBB4A (0.37) | GPR84KDRMAPTRAB9ADAO | |
| SCHEMBL6090481 | 0.73 | DAO (0.35) | GPR84KDRDAOALDH1A1 | |
| SCHEMBL6088351 | 0.72 | KDR (0.56) | KDRMAPTALOX15MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |