Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.41 |
| ▸ | ILK | Q13418 | 5/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30924197 | 0.89 | EGFR (0.46) | EGFRILKERBB2GAKPLK4 | |
| SCHEMBL2971332 | 0.89 | EGFR (0.46) | EGFRILKERBB2GAKPLK4 | |
| SCHEMBL6358005 | 0.87 | FFAR1 (0.37) | EGFRILKERBB2GAKPLK4 | |
| SCHEMBL4750637 | 0.84 | TBXAS1 (0.46) | — | |
| SCHEMBL1772406 | 0.79 | EGFR (0.45) | EGFRILKLMNACYP3A4MAPK1 | |
| SCHEMBL13645864 | 0.79 | DRD2 (0.50) | CYP3A4CYP1A2CYP2D6MAPK1CYP2C19 | |
| SCHEMBL6089644 | 0.78 | APP (0.41) | CYP1A2CYP2D6MAPK1CYP2C19CTNNB1 | |
| SCHEMBL6087766 | 0.78 | CHRNB2 (0.53) | CYP3A4CYP1A2CYP2D6MAPK1CYP2C19 | |
| SCHEMBL9369921 | 0.77 | KCNA3 (0.50) | CYP1A2CYP2C19CA2ALDH1A1 | |
| SCHEMBL12251491 | 0.76 | TP53 (0.53) | LMNACYP3A4FGFR2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |