Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30885179 | 0.82 | RAB9A (0.66) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL19553834 | 0.82 | RAB9A (0.66) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL18572645 | 0.82 | SMN1; SMN2 (0.50) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL14147454 | 0.77 | NLRP3 (0.48) | KDM4ENFKB1CYP1A2CYP3A4PKM | |
| SCHEMBL22926769 | 0.74 | NPC1 (0.63) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL14980555 | 0.74 | NPC1 (0.63) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL15560182 | 0.73 | CYSLTR1 (0.51) | OPRK1CYSLTR2CYSLTR1 | |
| Hydrochloric Acid SCHEMBL15549877 | 0.72 | CYSLTR1 (0.50) | OPRK1CYSLTR2CYSLTR1 | |
| SCHEMBL6089769 | 0.72 | CYSLTR1 (0.53) | KDM4ESMN1; SMN2HTTCYP3A4KMT2A | |
| SCHEMBL6090056 | 0.71 | ELANE (0.49) | HDAC6NPC1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |