Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28230139 | 0.85 | CYP3A4 (0.55) | CYSLTR1CYSLTR2GPBAR1MAPTMEN1 | |
| SCHEMBL1010648 | 0.84 | MEN1 (0.53) | CYSLTR1CYSLTR2MAPTMEN1KMT2A | |
| SCHEMBL28787263 | 0.84 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2GPBAR1MAPTMEN1 | |
| SCHEMBL14763914 | 0.81 | CYP3A4 (0.48) | CYSLTR1CYSLTR2MEN1KMT2AHTT | |
| SCHEMBL6089190 | 0.78 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6627563 | 0.76 | MEN1 (0.49) | CYSLTR1CYSLTR2MAPTMEN1KMT2A | |
| SCHEMBL8621924 | 0.75 | LMNA (0.50) | CYSLTR1CYSLTR2MAPTMEN1KMT2A | |
| SCHEMBL9485359 | 0.75 | ADAMTS4 (0.57) | CYSLTR1CYSLTR2MAPTMEN1KMT2A | |
| SCHEMBL15560182 | 0.74 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1OPRK1OPRM1 | |
| SCHEMBL6090607 | 0.73 | MAPT (0.46) | CYSLTR1CYSLTR2GPBAR1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |